Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 13/20 | 0.58 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.58 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.58 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | PKLR | P30613 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9293218 | 1.00 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9293220 | 1.00 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9294627 | 0.90 | ABCC9 (0.59) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9294620 | 0.90 | ABCC9 (0.59) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9294617 | 0.90 | ABCC9 (0.59) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9294148 | 0.89 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9294156 | 0.89 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9294151 | 0.89 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| Rilmakalim SCHEMBL9585284 | 0.88 | ABCC9 (0.63) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| Rilmakalim SCHEMBL9293204 | 0.88 | ABCC9 (0.63) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364878-A | Antiasthmatics; urogenital disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-15 | — | — | US | disclosed |
| US-4999371-A | Treating Cardiovascular Disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-12 | — | — | US | disclosed |