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SCHEMBL9294902

SCHEMBL9294902

CCCCc1nc2ccc(C3(C)CC4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.[NaH]

nearest known ligand 0.73

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ AGT P01019 4/20 0.61
▸ AGTR1 P30556 2/20 0.58
▸ AGTR2 P50052 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9294906 1.00 AGT (0.61) AGTAGTR1AGTR2
SCHEMBL9295715 0.99 AGT (0.61) AGTAGTR1AGTR2
SCHEMBL9295272 0.99 AGT (0.61) AGTAGTR1AGTR2
SCHEMBL9295278 0.99 AGT (0.61) AGTAGTR1AGTR2
SCHEMBL9295066 0.89 AGT (0.74) AGTAGTR1AGTR2
SCHEMBL9294927 0.89 AGT (0.74) AGTAGTR1AGTR2
SCHEMBL9294944 0.89 AGT (0.74) AGTAGTR1AGTR2
SCHEMBL9295030 0.89 AGT (0.74) AGTAGTR1AGTR2
SCHEMBL9295022 0.88 AGT (0.72) AGTAGTR1AGTR2
SCHEMBL9295706 0.88 AGT (0.72) AGTAGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0621276-A1 Angiotensin II receptor blocking 2,3,6-substituted quinazolinones AMERICAN CYANAMID COMPANY (US) 1994-10-26 — — EP disclosed
US-5358951-A Treating hypertension, congestive heart failure AMERICAN CYANAMID COMPANY (US) 1994-10-25 — — US disclosed
US-5292734-A Angiotensin II receptor blocking 2,3,6 substituted quinazolinones AMERICAN CYANAMID COMPANY (US) 1994-03-08 — — US disclosed