Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | LPL | P06858 | 6/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12062388 | 0.92 | CA1 (0.48) | HDAC1HDAC3HDAC2NCOR2CA1 | |
| SCHEMBL13180767 | 0.89 | HDAC3 (0.46) | HDAC1HDAC3HDAC2NCOR2CA1 | |
| SCHEMBL13528048 | 0.86 | HDAC3 (0.40) | HDAC1HDAC3HDAC2NCOR2CA1 | |
| SCHEMBL4461691 | 0.85 | HDAC1 (0.49) | HDAC1HDAC3HDAC2NCOR2TRPV1 | |
| SCHEMBL17393769 | 0.83 | HDAC1 (0.49) | HDAC1HDAC3HDAC2NCOR2SSTR4 | |
| SCHEMBL3141997 | 0.83 | HDAC1 (0.49) | HDAC1HDAC3HDAC2NCOR2SSTR4 | |
| SCHEMBL9060170 | 0.83 | HDAC1 (0.60) | HDAC1HDAC3HDAC2NCOR2HDAC6 | |
| SCHEMBL2882035 | 0.82 | HDAC1 (0.48) | HDAC1HDAC3HDAC2NCOR2SSTR4 | |
| SCHEMBL14328 | 0.82 | CA14 (0.45) | HDAC1HDAC3HDAC2NCOR2CA1 | |
| SCHEMBL7655742 | 0.81 | HDAC1 (0.47) | HDAC1HDAC3HDAC2NCOR2SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5326776-A | Tetrazoles | ABBOTT LABORATORIES (US) | 1994-07-05 | — | — | US | disclosed |
| US-5250548-A | Treating hypertension, heart failure | ABBOTT LABORATORIES (US) | 1993-10-05 | — | — | US | disclosed |
| WO-1993018035-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1993-09-16 | — | — | WO | disclosed |
| WO-1993017682-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1993-09-16 | — | — | WO | disclosed |