Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10348526 | 1.00 | MAOB (0.56) | MAOBKMT2AMAPTMEN1LMNA | |
| SCHEMBL11547347 | 0.91 | MEN1 (0.60) | MAOBKMT2AMAPTMEN1LMNA | |
| SCHEMBL11155039 | 0.90 | MAOB (0.55) | MAOBKMT2AMAPTMEN1LMNA | |
| SCHEMBL11155480 | 0.90 | MAOB (0.55) | MAOBKMT2AMAPTMEN1LMNA | |
| SCHEMBL11801921 | 0.89 | PTGS2 (0.63) | MAOBKMT2AMAPTMEN1LMNA | |
| SCHEMBL10544117 | 0.89 | PTGS2 (0.63) | MAOBKMT2AMAPTMEN1LMNA | |
| SCHEMBL11548191 | 0.86 | MEN1 (0.55) | MAOBKMT2AMAPTMEN1LMNA | |
| SCHEMBL10666472 | 0.84 | SMN1; SMN2 (0.62) | MAOBKMT2AMAPTMEN1LMNA | |
| SCHEMBL6985307 | 0.84 | SMN1; SMN2 (0.62) | MAOBKMT2AMAPTMEN1LMNA | |
| SCHEMBL6985305 | 0.84 | SMN1; SMN2 (0.62) | MAOBKMT2AMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993009774-A1 | 2-(4-SUBSTITUTED)PHENYLMETHYLENE DERIVATIVES AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1993-05-27 | — | — | WO | claimed |
| EP-0239105-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 5-PHENYL-1,3-DIOXOALKENYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-23 | — | — | EP | claimed |
| EP-0239105-A2 | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds | G.D. Searle & Co. (US) | 1987-09-30 | — | — | EP | claimed |
| US-5280047-A | Inhibiting 5-lipoxygenase in mammals | G. D. SEARLE & CO. (US) | 1994-01-18 | — | — | US | disclosed |
| WO-1993009774-A1 | 2-(4-SUBSTITUTED)PHENYLMETHYLENE DERIVATIVES AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1993-05-27 | — | — | WO | disclosed |
| EP-0239105-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 5-PHENYL-1,3-DIOXOALKENYL COMPOUNDS | G.D. Searle & Co. (US) | 1990-05-23 | — | — | EP | disclosed |
| US-4761503-A | LEUKOTRIENE BIOSYNTHESIS INHIBITORS CONDENSATION OF BENZALDEHYDE WITH ACETOACETATE COMPOUND | G. D. SEARLE & CO. (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0239105-A2 | Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl compounds | G.D. Searle & Co. (US) | 1987-09-30 | — | — | EP | disclosed |
| US-4649157-A | ANTIALLERGENS, ANTIINFLAMMATORY | G. D. SEARLE & CO. (US) | 1987-03-10 | — | — | US | disclosed |
| US-3932645-A | CORONARY VASODILATORS, HYPOTENSIVE AGENTS | FARBENFABRIKEN BAYER AG (DT) | 1976-01-13 | — | — | US | disclosed |