Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 14/20 | 0.72 |
| ▸ | ABCC9 | O60706 | 8/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | GLA | P06280 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9298619 | 1.00 | KCNJ11 (0.72) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL7758063 | 0.87 | KCNJ11 (0.64) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL7758066 | 0.87 | KCNJ11 (0.64) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL8140974 | 0.85 | ABCC9 (0.71) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL8140969 | 0.85 | ABCC9 (0.71) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL8140968 | 0.85 | ABCC9 (0.71) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 | |
| Pinacidil Anhydrous SCHEMBL1650693 | 0.84 | ABCC9 (1.00) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 | |
| Naminidil SCHEMBL1650535 | 0.84 | ABCC9 (1.00) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 | |
| Pinacidil Anhydrous SCHEMBL9351684 | 0.84 | ABCC9 (1.00) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 | |
| Naminidil SCHEMBL6375460 | 0.84 | ABCC9 (1.00) | KCNJ11ABCC9CYP3A4CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354553-A2 | Aryl cyanoguanidines: potassium channel activators and method of making same | E.R. SQUIBB & SONS, INC. (US) | 1990-02-14 | — | — | EP | claimed |
| US-5278169-A | Method of treating or prevention of fibrillation of the heart | E. R. SQUIBB & SONS, INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5011837-A | Aryl cyanoguanidines: potassium channel activators and method of making same | E. R. SQUIBB & SONS, INC. (US) | 1991-04-30 | — | — | US | disclosed |