Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 10/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299619 | 0.90 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL9300169 | 0.88 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL9299082 | 0.85 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL9300325 | 0.84 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL9299844 | 0.84 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL9299888 | 0.84 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL9299446 | 0.83 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7267833 | 0.81 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL9299606 | 0.80 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL8085320 | 0.79 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296492-A | Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0518342-A1 | Chroman derivatives | Nippon Kayaku Kabushiki Kaisha (JP) | 1992-12-16 | — | — | EP | disclosed |