Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 4/20 | 0.34 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9300617 | 1.00 | GABRR1 (0.34) | GABRR1GABRR2PLGPLATLMNA | |
| SCHEMBL2899608 | 0.84 | — | — | |
| Oxalic Acid SCHEMBL28622155 | 0.65 | GABRR1 (0.50) | GABRR1GABRR2PLGPLATLMNA | |
| Oxalic Acid SCHEMBL736575 | 0.65 | PLG (0.68) | GABRR1GABRR2PLGPLATLMNA | |
| SCHEMBL8531514 | 0.65 | FOLH1 (0.41) | LMNAOR51E2 | |
| Oxalic Acid SCHEMBL5874900 | 0.65 | FFAR3 (0.47) | GABRR1GABRR2LMNAGLRA1SLC6A9 | |
| Oxalic Acid SCHEMBL5171936 | 0.65 | — | — | |
| Oxalic Acid SCHEMBL31377007 | 0.64 | — | — | |
| Oxalic Acid SCHEMBL7573989 | 0.61 | OR51E2 (0.50) | GABRR1GABRR2PLGLMNAGLRA1 | |
| Oxalic Acid SCHEMBL5181650 | 0.61 | OR51E2 (0.50) | GABRR1GABRR2PLGLMNAGLRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374739-A | Antitumor agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0294828-B1 | MITOMYCIN ANALOGS, A PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS | Bristol-Myers Squibb Company (US) | 1993-08-25 | — | — | EP | disclosed |
| EP-0294828-A2 | Mitomycin analogs, a process for preparing them and pharmaceutical compositions | Bristol-Myers Squibb Company (US) | 1988-12-14 | — | — | EP | disclosed |