SCHEMBL9300620

SCHEMBL9300620

CN1C(C)(C)CC(NC(=O)CCC(=O)NN)CC1(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.41
POLB P06746 1/20 0.41
GAA P10253 2/20 0.39
MAPT P10636 1/20 0.38
KDM4E B2RXH2 2/20 0.37
CTSD P07339 1/20 0.37
KDM5C P41229 1/20 0.37
PHF8 Q9UPP1 1/20 0.37
KDM2A Q9Y2K7 1/20 0.37
EPHX2 P34913 2/20 0.35
MAOB P27338 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
SIGMAR1 Q99720 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
EPHX1 P07099 1/20 0.32
FLT3 P36888 1/20 0.32
TYRO3 Q06418 1/20 0.32
MERTK Q12866 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13298035 0.83 SMN1; SMN2 (0.47) GAAEPHX2ALDH1A1HDAC6SMN1; SMN2
SCHEMBL11046524 0.83 MAOB (0.39) HTTPOLBGAAMAPTKDM4E
SCHEMBL13871636 0.83 TSHR (0.41) GAAEPHX2SMN1; SMN2EPHX1
SCHEMBL8333479 0.83 POLB (0.40) HTTPOLBMAPTKDM4ECTSD
SCHEMBL9419550 0.81 GAA (0.35) HTTPOLBGAAMAPTKDM4E
SCHEMBL10156196 0.81 GAA (0.39) HTTGAAKDM4EEPHX2MAOB
SCHEMBL9003139 0.81 EZH2 (0.35) HTTPOLBGAAMAPTKDM4E
SCHEMBL9002615 0.80 SMN1; SMN2 (0.38) HTTPOLBGAAMAPTCTSD
SCHEMBL8771887 0.80 MAOB (0.37) HTTPOLBGAAMAPTKDM4E
SCHEMBL8336929 0.80 HDAC4 (0.36) GAAKDM4EEPHX2HDAC4HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9238609-B2 Dicarboxylic acid monomers and methods of making and using the same SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2016-01-19 US disclosed
US-20150336869-A1 DICARBOXYLIC ACID MONOMERS AND METHODS OF MAKING AND USING THE SAME SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-26 US disclosed
US-20150322200-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 US disclosed
WO-2015171709-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 WO disclosed
US-8633265-B2 UV stabilization of isosorbide polycarbonates SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2014-01-21 US disclosed
EP-2665775-A1 UV STABILIZATION OF ISOSORBIDE POLYCARBONATES SABIC Innovative Plastics IP B.V. (NL) 2013-11-27 EP disclosed
WO-2012098513-A1 UV STABILIZATION OF ISOSORBIDE POLYCARBONATES SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-07-26 WO disclosed
US-20120184651-A1 UV Stabilization of Isosorbide Polycarbonates SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2012-07-19 US disclosed
US-RE34791-E Polymer bound hindered amine light stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1994-11-15 US disclosed
EP-0303987-B1 POLYMER BOUND HINDERED AMINE LIGHT STABILIZERS ATOCHEM NORTH AMERICA, INC. (US) 1992-10-14 EP disclosed
US-4978699-A Reaction product of hindered amine with primary amine or reactive hydrazide group and halogenated cyclic anhydride; for extrusion with polymers ATOCHEM NORTH AMERICA, INC. (US) 1990-12-18 US disclosed
US-4975489-A Heating an anhydride-containing polymer with a hydrazine derivative of a 2,2,6,6-tetramethyl-4-aminopiperidine in an inert solvent of by melt blending ATOCHEM NORTH AMERICA, INC. (US) 1990-12-04 US disclosed
EP-0366057-A2 Light stabilizing flame retardants ATOCHEM NORTH AMERICA, INC. (a Pennsylvania corp.) (US) 1990-05-02 EP disclosed
US-4857595-A Polymer bound hindered amine light stabilizers PENNWALT CORPORATION (US) 1989-08-15 US disclosed
US-4824884-A Cyclic anhydride derivatives of hydrazide functionalized hindered amine light stabilizers PENNWALT CORPORATION (US) 1989-04-25 US disclosed
EP-0303987-A2 Polymer bound hindered amine light stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1989-02-22 EP disclosed
EP-0303282-A2 Cyclic anhydride derivatives of hydrazide functionalized hindered amine light stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1989-02-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150336869-A1 DICARBOXYLIC ACID MONOMERS AND METHODS OF MAKING AND USING THE SAME PGD, CDA, PPIA HTT 1924/4885POLB 937/4885GAA 995/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.