Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 9/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299718 | 0.95 | TOP2A (0.64) | TOP2APDE5AELANECYP4F2CYP4A11 | |
| SCHEMBL9300532 | 0.91 | TOP2A (0.62) | TOP2APDE5AELANECYP4F2CYP4A11 | |
| SCHEMBL9301425 | 0.89 | TOP2A (0.53) | TOP2APDE5AELANECYP4F2CYP4A11 | |
| SCHEMBL9301382 | 0.88 | TOP2A (0.53) | TOP2APDE5AELANECYP4F2CYP4A11 | |
| SCHEMBL9300657 | 0.86 | TOP2A (0.53) | TOP2APDE5AELANECYP4F2CYP4A11 | |
| SCHEMBL9300838 | 0.85 | TOP2A (0.54) | TOP2APDE5AELANECYP4F2CYP4A11 | |
| SCHEMBL9300814 | 0.84 | TOP2A (0.64) | TOP2APDE5AELANECYP4F2CYP4A11 | |
| SCHEMBL9300903 | 0.83 | TOP2A (0.51) | TOP2APDE5ACYP4F2CYP4A11POLB | |
| SCHEMBL9300665 | 0.82 | TOP2A (0.52) | TOP2APDE5AELANECYP4F2CYP4A11 | |
| SCHEMBL9299935 | 0.81 | TOP2A (0.68) | TOP2APDE5AELANEPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | claimed |