Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 12/20 | 0.64 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9299935 | 0.97 | TOP2A (0.68) | TOP2ATOP2BPDE5AELANEKDM4E | |
| SCHEMBL9300797 | 0.93 | TOP2A (0.67) | TOP2ATOP2BPDE5AELANEKDM4E | |
| SCHEMBL9300642 | 0.90 | TOP2A (0.60) | TOP2ATOP2BPDE5AELANEKDM4E | |
| SCHEMBL9299913 | 0.87 | TOP2A (0.60) | TOP2ATOP2BELANEKDM4EPOLB | |
| SCHEMBL9299722 | 0.87 | TOP2A (0.64) | TOP2ATOP2BPDE5AELANEKDM4E | |
| SCHEMBL9300639 | 0.84 | TOP2A (0.60) | TOP2ATOP2BPDE5AELANEKDM4E | |
| SCHEMBL9301580 | 0.84 | TOP2A (0.71) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9300538 | 0.83 | TOP2A (0.63) | TOP2ATOP2BPDE5AELANEKDM4E | |
| SCHEMBL9299690 | 0.81 | TOP2A (0.73) | TOP2ATOP2BKDM4EPOLBGLA | |
| SCHEMBL9299718 | 0.81 | TOP2A (0.64) | TOP2ATOP2BPDE5AELANEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | claimed |