Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | NAAA | Q02083 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 6/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9299990 | 1.00 | CHRM2 (0.41) | CHRM2CHRM5CHRM1CHRM3ALDH1A1 | |
| Iodide SCHEMBL9299984 | 1.00 | CHRM2 (0.41) | CHRM2CHRM5CHRM1CHRM3ALDH1A1 | |
| Iodide SCHEMBL9301277 | 0.85 | CHRM2 (0.39) | CHRM2CHRM5CHRM1CHRM3ALDH1A1 | |
| Iodide SCHEMBL9301287 | 0.85 | CHRM2 (0.39) | CHRM2CHRM5CHRM1CHRM3ALDH1A1 | |
| Iodide SCHEMBL9302101 | 0.84 | CHRM2 (0.39) | CHRM2CHRM5CHRM1CHRM3ALDH1A1 | |
| Iodide SCHEMBL9302107 | 0.84 | CHRM2 (0.39) | CHRM2CHRM5CHRM1CHRM3ALDH1A1 | |
| SCHEMBL16478654 | 0.72 | NAAA (0.50) | ALDH1A1NAAAMAPK1PRKCA | |
| SCHEMBL16478678 | 0.72 | NAAA (0.50) | ALDH1A1NAAAMAPK1PRKCA | |
| SCHEMBL8948434 | 0.70 | CHRM2 (0.48) | CHRM2CHRM5CHRM1CHRM3ALDH1A1 | |
| SCHEMBL8948401 | 0.70 | CHRM2 (0.50) | CHRM2CHRM5CHRM1CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356885-A | Cholinergic agents; administering for treatment of diseases of the central nervous system | AMERICAN CYANAMID COMPANY (US) | 1994-10-18 | — | — | US | claimed |