SCHEMBL9300700

SCHEMBL9300700

NC(CCCCNc1ccccc1[N+](=O)[O-])C(=O)O

nearest known ligand 0.71

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KAT2B Q92831 2/20 0.60
ALDH1A1 P00352 1/20 0.51
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
MAPT P10636 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
GRM8 O00222 1/20 0.46
GRM4 Q14833 1/20 0.46
HCAR3 P49019 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9300696 1.00 KAT2B (0.60) KAT2BALDH1A1NPC1RAB9AMAPT
Hydrochloric Acid SCHEMBL10437435 0.99 KAT2B (0.61) KAT2BALDH1A1NPC1RAB9AMAPT
SCHEMBL8749857 0.89 KAT2B (0.47) KAT2BALDH1A1MAPTMEN1KMT2A
Hydrochloric Acid SCHEMBL9225184 0.88 KAT2B (0.48) KAT2BALDH1A1GRM8GRM4HCAR3
SCHEMBL31083493 0.84 ALDH1A1 (0.57) ALDH1A1NPC1MAPTMEN1KMT2A
SCHEMBL6226433 0.84 ALDH1A1 (0.57) ALDH1A1NPC1MAPTMEN1KMT2A
SCHEMBL295431 0.84 ALDH1A1 (0.57) ALDH1A1NPC1MAPTMEN1KMT2A
Hydrochloric Acid SCHEMBL29399068 0.83 ALDH1A1 (0.56) KAT2BALDH1A1MAPTGRM8GRM4
SCHEMBL9299748 0.83 KAT2B (0.62) KAT2BALDH1A1MAPTGRM8GRM4
Hydrochloric Acid SCHEMBL1567843 0.83 ALDH1A1 (0.56) KAT2BALDH1A1MAPTGRM8GRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994012163-A1 2-NITROARYL AND 2-CYANOARYL COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE ABBOTT LABORATORIES (US) 1994-06-09 WO claimed
US-5362747-A Promoters, inhibitors ABBOTT LABORATORIES (US) 1994-11-08 US disclosed
WO-1994012163-A1 2-NITROARYL AND 2-CYANOARYL COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE ABBOTT LABORATORIES (US) 1994-06-09 WO disclosed