SCHEMBL9300875

SCHEMBL9300875

[SiH2]Cc1ccccc1-c1cccc2ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.45
CYP2C19 P33261 2/20 0.45
CYP2C9 P11712 1/20 0.45
ALDH1A1 P00352 2/20 0.44
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
HPGD P15428 1/20 0.44
KMT2A Q03164 1/20 0.44
ACP3 P15309 1/20 0.44
CYP2D6 P10635 2/20 0.42
TDP1 Q9NUW8 2/20 0.41
CYP2A6 P11509 1/20 0.39
TSHR P16473 1/20 0.39
HSD17B10 Q99714 1/20 0.39
CTNNB1 P35222 1/20 0.39
PTPN1 P18031 1/20 0.38
KDM4E B2RXH2 1/20 0.38
ALPL P05186 1/20 0.38
GAA P10253 1/20 0.38
KCNA5 P22460 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL781800 0.82 CYP1A2 (0.58) CYP1A2CYP2C19CYP2C9ALDH1A1MEN1
SCHEMBL477544 0.81 PDCD1 (0.47) CYP1A2CYP2C19CYP2C9ALDH1A1MEN1
SCHEMBL31517086 0.79 CYP1A2 (0.45) CYP1A2CYP2C19CYP2C9ALDH1A1MEN1
SCHEMBL4438778 0.79 CYP1A2 (0.45) CYP1A2CYP2C19CYP2C9ALDH1A1MEN1
SCHEMBL11650416 0.79 CYP1A2 (0.45) CYP1A2CYP2C19CYP2C9ALDH1A1MEN1
SCHEMBL3101185 0.79 CYP1A2 (0.45) CYP1A2CYP2C19CYP2C9ALDH1A1MEN1
SCHEMBL2992860 0.79 MEN1 (0.49) CYP1A2CYP2C19CYP2C9ALDH1A1MEN1
SCHEMBL26774 0.79 CYP1A2 (0.45) CYP1A2CYP2C19CYP2C9ALDH1A1MEN1
SCHEMBL25302086 0.79 ALDH1A1 (0.59) CYP1A2ALDH1A1MAPTHPGDTDP1
SCHEMBL29350007 0.79 ALDH1A1 (0.59) CYP1A2ALDH1A1MAPTHPGDTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5354772-A Anticholesterol agents SANDOZ PHARM. CORP. (US) 1994-10-11 US disclosed
EP-0200736-B1 PYRAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE SANDOZ AG (CH) 1991-04-24 EP disclosed
US-5001255-A Idene analogs of mevalonolactone and derivatives thereof SANDOZ PHARM. CORP. (US) 1991-03-19 US disclosed
EP-0216785-B1 INDENE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF SANDOZ AG (CH) 1991-01-30 EP disclosed
US-4973704-A ANTICHOLESTEROL AGENTS SANDOZ PHARM. CORP. (US) 1990-11-27 US disclosed
EP-0235164-B1 IMIDAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF SANDOZ AG (CH) 1990-07-25 EP disclosed
US-4939159-A Azaindole derivatives useful as cholesterol biosynthesis inhibitors SANDOZ PHARM. CORP. (US) 1990-07-03 US disclosed
US-4876280-A ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS; ANTILIPEMICS SANDOZ PHARM. CORP. (US) 1989-10-24 US disclosed
EP-0327500-A2 5-Substituted 1H-pyrazolo[3,4-b]pyridine derivatives, their preparation and pharmaceutical compositions containing them SANDOZ AG (CH) 1989-08-09 EP disclosed
US-4851427-A INHJIBITORS OF CHOLESTEROL BIOSYNTHESIS SANDOZ PHARM. CORP. (US) 1989-07-25 US disclosed
WO-1986007054-A1 IMIDAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF SANDOZ AG (CH) 1986-12-04 WO disclosed
EP-0200736-A1 PYRAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE. SANDOZ AG (CH) 1986-11-12 EP disclosed
EP-0117228-B1 ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS SANDOZ AG (CH) 1986-11-05 EP disclosed
US-4613610-A TREATING ATHEROSCLEROSIS AND HYPERLIPEMIA SANDOZ PHARMACEUTICALS CORP. (US) 1986-09-23 US disclosed
WO-1986003488-A1 INDENE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF SANDOZ AG (CH) 1986-06-19 WO disclosed
WO-1986000307-A2 PYRAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE SANDOZ AG (CH) 1986-01-16 WO disclosed
EP-0117228-A1 Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals SANDOZ AG (CH) 1984-08-29 EP disclosed
WO-1984002903-A1 MEVALONOLACTONE ANALOGS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS SANDOZ AG (CH) 1984-08-02 WO disclosed
EP-0114027-A1 Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals SANDOZ AG (CH) 1984-07-25 EP disclosed
WO-1984002131-A1 ANALOGS OF MEVALOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS SANDOZ AG (CH) 1984-06-07 WO disclosed