Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.69 |
| ▸ | MEN1 | O00255 | 9/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | PKM | P14618 | 3/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 11/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12267450 | 0.90 | MAPT (0.75) | KMT2AMEN1ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL197261 | 0.90 | MAPT (0.75) | KMT2AMEN1ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL197262 | 0.90 | MAPT (0.75) | KMT2AMEN1ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL24345234 | 0.85 | MAPT (0.73) | KMT2AMEN1ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL1753097 | 0.85 | MAPT (0.73) | KMT2AMEN1ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL16080106 | 0.81 | MAPT (0.62) | KMT2AMEN1ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL5803667 | 0.74 | MAPT (0.47) | KMT2AMEN1ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL19721178 | 0.74 | MAPT (0.68) | KMT2AMEN1ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL6799713 | 0.73 | POLB (0.71) | KMT2AMEN1ALDH1A1MAPTCRHBP | |
| SCHEMBL6799710 | 0.73 | POLB (0.71) | KMT2AMEN1ALDH1A1MAPTCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308852-A | Cardiovascular disorders | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0579304-A1 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1994-01-19 | — | — | EP | disclosed |
| WO-1994000444-A1 | HETEROARYLNAPHTHALENES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-01-06 | — | — | WO | disclosed |