Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 5/20 | 0.40 |
| ▸ | RAD52 | P43351 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301922 | 0.86 | TOP2A (0.43) | TOP2ATOP2BPOLBRAD52GAA | |
| SCHEMBL9547245 | 0.81 | TOP2A (0.48) | TOP2ATOP2BPOLBRAD52GAA | |
| SCHEMBL9547265 | 0.79 | TOP2A (0.46) | TOP2ATOP2BPOLBRAD52GAA | |
| SCHEMBL9300764 | 0.78 | TOP2B (0.53) | TOP2ATOP2BPOLBRAD52GAA | |
| SCHEMBL9301751 | 0.78 | TOP2B (0.47) | TOP2ATOP2BPOLBRAD52GAA | |
| SCHEMBL9301604 | 0.76 | TOP2B (0.45) | TOP2ATOP2BPOLBRAD52GAA | |
| SCHEMBL9300829 | 0.75 | TOP2B (0.47) | TOP2ATOP2BPOLBRAD52GAA | |
| SCHEMBL9300532 | 0.75 | TOP2A (0.62) | TOP2ATOP2BPOLBGAARAB9A | |
| SCHEMBL9299718 | 0.75 | TOP2A (0.64) | TOP2ATOP2BPOLBRAD52KDM4E | |
| SCHEMBL9302086 | 0.74 | TOP2A (0.50) | TOP2ATOP2BPOLBRAD52GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354864-A | Antitumor agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-10-11 | — | — | US | claimed |
| WO-1993023049-A1 | 3-(9-ACRIDINYLAMINO)-5-HYDROXYMETHYLANILINE DERIVATIVES AS ANTICANCER AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-11-25 | — | — | WO | claimed |