Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 1/20 | 0.59 |
| ▸ | CHRNG | P07510 | 1/20 | 0.59 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | CHRND | Q07001 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25385568 | 0.84 | NPC1 (0.53) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL14867646 | 0.84 | KMT2A (0.51) | RAB9AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL12553737 | 0.83 | MAPT (0.46) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL5601531 | 0.82 | HDAC6 (0.59) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL27007874 | 0.82 | CHRNA1 (0.53) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL6423147 | 0.81 | POLB (0.48) | RAB9AMAPTALDH1A1CYP2C19MEN1 | |
| SCHEMBL16823591 | 0.81 | MAPT (0.53) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL8507005 | 0.80 | HDAC6 (0.53) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL30107275 | 0.80 | HDAC6 (0.53) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL1933083 | 0.79 | ALDH1A1 (0.59) | RAB9AMAPTALDH1A1CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356893-A | Antidepressants, nervous system disorders | GLAXO GROUP LIMITED (GB) | 1994-10-18 | — | — | US | disclosed |
| EP-0533266-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |