Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 9/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ABCC9 | O60706 | 9/20 | 0.54 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.50 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301535 | 1.00 | ABCB1 (0.56) | ABCB1CYP3A4ALOX15ABCC9ABCC8 | |
| SCHEMBL9301539 | 1.00 | ABCB1 (0.56) | ABCB1CYP3A4ALOX15ABCC9ABCC8 | |
| SCHEMBL9300000 | 0.90 | ABCB1 (0.55) | ABCB1CYP3A4ALOX15ABCC9ABCC8 | |
| SCHEMBL9300003 | 0.90 | ABCB1 (0.55) | ABCB1CYP3A4ALOX15ABCC9ABCC8 | |
| SCHEMBL9300023 | 0.90 | CYP3A4 (0.51) | ABCB1CYP3A4ALOX15ABCC9ABCC8 | |
| SCHEMBL9300027 | 0.90 | CYP3A4 (0.51) | ABCB1CYP3A4ALOX15ABCC9ABCC8 | |
| SCHEMBL9300021 | 0.90 | CYP3A4 (0.51) | ABCB1CYP3A4ALOX15ABCC9ABCC8 | |
| SCHEMBL9300075 | 0.88 | ABCC9 (0.57) | ABCB1CYP3A4ALOX15ABCC9ABCC8 | |
| SCHEMBL9300069 | 0.88 | ABCC9 (0.57) | ABCB1CYP3A4ALOX15ABCC9ABCC8 | |
| SCHEMBL9300079 | 0.88 | ABCC9 (0.57) | ABCB1CYP3A4ALOX15ABCC9ABCC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296492-A | Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0518342-A1 | Chroman derivatives | Nippon Kayaku Kabushiki Kaisha (JP) | 1992-12-16 | — | — | EP | disclosed |