Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9300444 | 0.88 | KAT2B (0.34) | TDP1MEN1KMT2AMAPTGAA | |
| SCHEMBL9301310 | 0.86 | MAPT (0.44) | TDP1MEN1KMT2AMAPTGAA | |
| SCHEMBL9301043 | 0.81 | KAT2B (0.35) | TDP1MEN1KMT2AMAPTLMNA | |
| SCHEMBL9299967 | 0.79 | MAPT (0.46) | TDP1MEN1KMT2AMAPTLMNA | |
| SCHEMBL9299952 | 0.79 | KCNMA1 (0.41) | TDP1MEN1KMT2AMAPTLMNA | |
| SCHEMBL9388637 | 0.78 | TDP1 (0.44) | TDP1MEN1KMT2AMAPTGAA | |
| SCHEMBL9300400 | 0.77 | NPSR1 (0.43) | TDP1MEN1KMT2AMAPTGAA | |
| SCHEMBL9300380 | 0.77 | MAPT (0.36) | TDP1MEN1KMT2AMAPTLMNA | |
| SCHEMBL9300395 | 0.74 | ATM (0.39) | TDP1MEN1KMT2AMAPTGAA | |
| SCHEMBL11066636 | 0.70 | TDP1 (0.55) | TDP1MEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5362747-A | Promoters, inhibitors | ABBOTT LABORATORIES (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1994012163-A1 | 2-NITROARYL AND 2-CYANOARYL COMPOUNDS AS REGULATORS OF NITRIC OXIDE SYNTHASE | ABBOTT LABORATORIES (US) | 1994-06-09 | — | — | WO | disclosed |