Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | ERN1 | O75460 | 8/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 3/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 3/20 | 0.46 |
| ▸ | TYR | P14679 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.39 |
| ▸ | ABAT | P80404 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1535289 | 0.81 | ALDH1A1 (0.44) | CA1CA2ERN1ALDH1A1TLR2 | |
| SCHEMBL29459741 | 0.80 | CA1 (0.69) | CA1CA2ERN1TRIM24TRIM33 | |
| SCHEMBL1003414 | 0.80 | CA1 (0.69) | CA1CA2ERN1TRIM24TRIM33 | |
| SCHEMBL1005010 | 0.78 | CA1 (0.61) | CA1CA2ERN1TRIM24TRIM33 | |
| SCHEMBL29459651 | 0.78 | CA1 (0.61) | CA1CA2ERN1TRIM24TRIM33 | |
| SCHEMBL7939012 | 0.77 | CA1 (0.59) | CA1CA2ERN1TRIM24TRIM33 | |
| SCHEMBL1361643 | 0.77 | CA1 (0.59) | CA1CA2ERN1TRIM24TRIM33 | |
| SCHEMBL92973 | 0.76 | ALDH1A1 (0.40) | CA1CA2ERN1ALDH1A1TLR2 | |
| SCHEMBL1396832 | 0.76 | CA1 (0.54) | CA1CA2ERN1TRIM24TRIM33 | |
| SCHEMBL8313384 | 0.76 | ERN1 (0.54) | ERN1TRIM24TRIM33TYRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107278204-A | Copanlisib and its dihydrochloride synthesis | 拜耳制药股份公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-107074776-A | Synthesis of Copanlisib and its Dihydrochloride | 拜耳制药股份公司 | 2017-08-18 | — | — | CN | disclosed |
| US-8129386-B2 | Fused azole-pyrimidine derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-06 | — | — | US | disclosed |
| US-20090270388-A1 | FUSED AZOLE-PYRIMIDINE DERIVATIVES | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-10-29 | — | — | US | disclosed |
| US-7511041-B2 | Fused azole-pyrimidine derivatives | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270388-A1 | FUSED AZOLE-PYRIMIDINE DERIVATIVES | PIK3CA, PIK3CD, PIK3R5 | CA1 2126/4885CA2 1581/4885ERN1 3061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.