Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 6/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pridinol SCHEMBL195084 | 0.76 | CYP2D6 (1.00) | CYP2D6MAPK1CHRM2CHRM1KCNH2 | |
| SCHEMBL8308440 | 0.76 | SCN1A (0.36) | CYP2D6MAPK1OPRM1LMNAMEN1 | |
| SCHEMBL8318293 | 0.75 | NR3C2 (0.38) | MAPK1CHRM2CHRM1LMNACHRM3 | |
| SCHEMBL11734176 | 0.73 | MAOB (0.41) | KMT2AACHEHRH3ALDH1A1 | |
| SCHEMBL10307557 | 0.72 | CHRM2 (0.61) | CYP2D6MAPK1CHRM2CHRM1KCNH2 | |
| Pridinol SCHEMBL10786634 | 0.72 | CYP2D6 (0.87) | CYP2D6MAPK1CHRM2CHRM1KCNH2 | |
| SCHEMBL11610162 | 0.72 | CHRM2 (0.74) | CYP2D6MAPK1CHRM2CHRM1KCNH2 | |
| SCHEMBL6699352 | 0.72 | CHRM2 (0.74) | CYP2D6MAPK1CHRM2CHRM1KCNH2 | |
| SCHEMBL10307555 | 0.71 | CHRM2 (0.59) | CYP2D6MAPK1CHRM2CHRM1KCNH2 | |
| Hydrochloric Acid SCHEMBL11608735 | 0.71 | CYP2D6 (0.72) | CYP2D6MAPK1CHRM2CHRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104262290-B | Preparation method of pridinol mesylate | 湖北工业大学 | 2017-01-11 | — | — | CN | disclosed |
| CN-103254154-A | Novel method for preparing mesylate pridinol | CHONGQING BEIBEI RES INST OF MODERN APPLIED MEDICINES | 2013-08-21 | — | — | CN | disclosed |
| US-5370880-A | Coated with mixture of copolymer containing (meth)acrylate esters, and ethyl cellulose | BURROUGHS WELLCOME CO. (US) | 1994-12-06 | — | — | US | disclosed |
| EP-0284408-B1 | PHARMACEUTICAL FORMULATIONS OF ACRIVASTINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-11-27 | — | — | EP | disclosed |
| US-4954350-A | CONTROLLED RELEASE ANTIHISTAMINE; COATING MIXTURE CONTAINING ETHYL CELLULOSE AND A (METH)ACRYLATE POLYMER | BURROUGHS WELLCOME CO. (US) | 1990-09-04 | — | — | US | disclosed |
| WO-1988007369-A1 | PHARMACEUTICAL FORMULATIONS | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-10-06 | — | — | WO | disclosed |
| EP-0284408-A1 | Pharmaceutical formulations of acrivastine | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-09-28 | — | — | EP | disclosed |
| US-4728513-A | HEAT TREATED FOR STORAGE STABILITY | ZYMA SA (CH) | 1988-03-01 | — | — | US | disclosed |