Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 2/20 | 0.38 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308440 | 0.89 | SCN1A (0.36) | NR3C2PSIP1KCNN4KIF11MAPK1 | |
| SCHEMBL8318667 | 0.85 | NR3C2 (0.38) | NR3C2PSIP1KCNN4KIF11MAPK1 | |
| SCHEMBL4656029 | 0.76 | VDR (0.42) | CA1CA2CA9LMNACYP2C19 | |
| SCHEMBL9302722 | 0.75 | CYP2D6 (0.61) | MAPK1LMNACHRM2CHRM1CHRM3 | |
| SCHEMBL7764290 | 0.74 | KCNN4 (0.43) | KCNN4KIF11MAPK1LMNACYP2C19 | |
| SCHEMBL29280866 | 0.74 | MAPK1 (0.48) | KCNN4KIF11MAPK1LMNA | |
| SCHEMBL8318529 | 0.74 | NR3C2 (0.43) | NR3C2KCNN4MAPK1CA1CA2 | |
| Hydrochloric Acid SCHEMBL27457472 | 0.73 | LMNA (0.42) | KCNN4MAPK1LMNA | |
| SCHEMBL6470484 | 0.73 | LMNA (0.50) | KCNN4MAPK1LMNA | |
| SCHEMBL7796544 | 0.71 | KCNN4 (0.40) | KCNN4KIF11MAPK1LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929534-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | Takeda Pharmaceutical Company Limited (JP) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013356-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-02 | — | — | WO | disclosed |
| WO-1997044329-A9 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | — | 1998-03-12 | — | — | WO | disclosed |