Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.51 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MDH2 | P40926 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9305354 | 0.83 | P2RY14 (0.60) | P2RY14ALOX5SLC16A3ALDH1A1HPGD | |
| SCHEMBL9303261 | 0.82 | P2RY14 (0.57) | P2RY14ALOX5SLC16A3ALDH1A1HPGD | |
| SCHEMBL9301998 | 0.81 | P2RY14 (0.61) | P2RY14ALOX5SLC16A3ALDH1A1HPGD | |
| SCHEMBL9301696 | 0.80 | P2RY14 (0.55) | P2RY14ALOX5SLC16A3ALDH1A1HPGD | |
| SCHEMBL9303687 | 0.80 | P2RY14 (0.57) | P2RY14ALOX5SLC16A3ALDH1A1HPGD | |
| SCHEMBL9302836 | 0.77 | P2RY14 (0.51) | P2RY14ALOX5SLC16A3ALDH1A1HPGD | |
| SCHEMBL9303702 | 0.74 | P2RY14 (0.53) | P2RY14ALOX5ALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL9303016 | 0.74 | P2RY14 (0.61) | P2RY14ALOX5ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL28102599 | 0.73 | P2RY14 (0.53) | P2RY14ALOX5SLC16A3ALDH1A1HPGD | |
| SCHEMBL28018447 | 0.73 | P2RY14 (0.53) | P2RY14ALOX5SLC16A3ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |