Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9305354 | 0.88 | P2RY14 (0.60) | P2RY14SMN1; SMN2ALDH1A1ALOX5MAOB | |
| SCHEMBL9303687 | 0.85 | P2RY14 (0.57) | P2RY14SMN1; SMN2ALDH1A1ALOX5MAOB | |
| SCHEMBL9303261 | 0.81 | P2RY14 (0.57) | P2RY14SMN1; SMN2ALDH1A1ALOX5MAOB | |
| SCHEMBL9303016 | 0.79 | P2RY14 (0.61) | P2RY14SMN1; SMN2ALDH1A1ALOX5MAOB | |
| SCHEMBL9301998 | 0.77 | P2RY14 (0.61) | P2RY14SMN1; SMN2ALDH1A1ALOX5MAOB | |
| SCHEMBL9301696 | 0.74 | P2RY14 (0.55) | P2RY14SMN1; SMN2ALDH1A1ALOX5MAOB | |
| SCHEMBL9302917 | 0.74 | P2RY14 (0.55) | P2RY14SMN1; SMN2ALDH1A1ALOX5MAOB | |
| SCHEMBL9302951 | 0.73 | P2RY14 (0.56) | P2RY14ALOX5MAOBMAOA | |
| SCHEMBL11690669 | 0.72 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9302836 | 0.71 | P2RY14 (0.51) | P2RY14SMN1; SMN2ALDH1A1ALOX5MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |