Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 2/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302862 | 0.87 | PTAFR (0.78) | PTAFRHRH3AGTR1AGTR2HDAC1 | |
| SCHEMBL9302148 | 0.85 | PTAFR (0.75) | PTAFRHRH3DRD2TBXA2RCYP2D6 | |
| SCHEMBL9301610 | 0.83 | PTAFR (1.00) | PTAFRHRH3HDAC1HDAC6 | |
| SCHEMBL9301924 | 0.81 | PTAFR (0.80) | PTAFRHRH3DRD2TBXA2R | |
| SCHEMBL9305049 | 0.81 | PTAFR (0.77) | PTAFRHRH3CYP2D6CHRM1HRH1 | |
| SCHEMBL9302757 | 0.81 | PTAFR (0.77) | PTAFRHRH3CYP2D6CHRM1HRH1 | |
| SCHEMBL9301789 | 0.81 | PTAFR (0.77) | PTAFRHRH3HDAC1HDAC6CYP2D6 | |
| SCHEMBL9301705 | 0.80 | PTAFR (0.75) | PTAFRHRH3CNR2CYP2D6CHRM1 | |
| SCHEMBL9302551 | 0.79 | PTAFR (0.74) | PTAFRHRH3DRD2TBXA2RCYP2D6 | |
| SCHEMBL9671619 | 0.79 | AGTR1 (0.58) | AGTR1AGTR2HDAC1HDAC6PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468971-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-02-05 | — | — | EP | claimed |
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | claimed |
| US-5314880-A | Platelet activating factor antagonist | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-05-24 | — | — | US | disclosed |
| EP-0468971-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |
| WO-1990009997-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1990-09-07 | — | — | WO | disclosed |