Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9157614 | 0.88 | CHRNB4 (0.40) | DRD3 | |
| SCHEMBL9154678 | 0.88 | DRD3 (0.33) | DRD3 | |
| SCHEMBL9159596 | 0.87 | DRD3 (0.32) | DRD3 | |
| SCHEMBL9302359 | 0.83 | HTR2C (0.38) | DRD3 | |
| SCHEMBL9261351 | 0.81 | DRD3 (0.38) | DRD3 | |
| SCHEMBL9264574 | 0.80 | DRD3 (0.34) | DRD3 | |
| SCHEMBL9154962 | 0.79 | DRD3 (0.35) | DRD3 | |
| SCHEMBL9157877 | 0.74 | DRD3 (0.32) | DRD3 | |
| SCHEMBL9265496 | 0.74 | — | — | |
| SCHEMBL6024998 | 0.69 | DRD2 (0.33) | DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |