Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302999 | 0.94 | ALOX5 (0.42) | ALOX5P2RY14 | |
| SCHEMBL9302868 | 0.93 | ALOX5 (0.42) | ALOX5MRGPRX4ANO1P2RY14 | |
| SCHEMBL9303269 | 0.89 | ALOX5 (0.43) | ALOX5MAOBP2RY14 | |
| SCHEMBL9267794 | 0.89 | ALOX5 (0.42) | ALOX5MRGPRX4P2RY14 | |
| SCHEMBL9265197 | 0.89 | ALOX5 (0.42) | ALOX5P2RY14 | |
| SCHEMBL9304055 | 0.88 | ALOX5 (0.43) | ALOX5MRGPRX4ANO1P2RY14 | |
| SCHEMBL9271846 | 0.88 | ALOX5 (0.44) | ALOX5MRGPRX4P2RY14 | |
| SCHEMBL9593897 | 0.87 | ALOX5 (0.42) | ALOX5MAOBMRGPRX4P2RY14 | |
| SCHEMBL9303146 | 0.86 | ALOX5 (0.42) | ALOX5P2RY14 | |
| SCHEMBL9304122 | 0.86 | ALOX5 (0.43) | ALOX5P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | claimed |
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |