Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | ACHE | P22303 | 2/20 | 0.65 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.62 |
| ▸ | CDK4 | P11802 | 1/20 | 0.62 |
| ▸ | CCND1 | P24385 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852870 | 0.96 | GFER (0.65) | KMT2AACHEMTNR1AMTNR1BCDK4 | |
| SCHEMBL11483618 | 0.91 | KMT2A (0.68) | KMT2AACHEMTNR1AMTNR1BCDK4 | |
| SCHEMBL9302255 | 0.85 | GFER (0.70) | KMT2AMTNR1AMEN1GFER | |
| SCHEMBL9117842 | 0.84 | MEN1 (0.76) | KMT2AMTNR1AMEN1NPC1RAB9A | |
| SCHEMBL9304098 | 0.84 | MEN1 (0.67) | KMT2AMTNR1AMEN1GFER | |
| SCHEMBL1520049 | 0.82 | KMT2A (0.66) | KMT2AACHECDK4CCND1MEN1 | |
| Hydrochloric Acid SCHEMBL11478621 | 0.82 | KMT2A (0.83) | KMT2AACHECDK4CCND1MEN1 | |
| SCHEMBL5871022 | 0.82 | KMT2A (0.73) | KMT2AACHECDK4CCND1MEN1 | |
| SCHEMBL7677886 | 0.82 | MEN1 (0.84) | KMT2AMTNR1AMEN1NPC1RAB9A | |
| SCHEMBL21255779 | 0.81 | KMT2A (0.69) | KMT2AMTNR1AMEN1GFERMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5283343-A | Melatonin antagonists | WHITBY RESEARCH, INC. (US) | 1994-02-01 | — | — | US | disclosed |
| US-5093352-A | Melatonin inhibitor, sleep, 2-aryl N-acetyl tryptamine | WHITBY RESEARCH, INC. (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0375726-A4 | MELATONIN ANALOGUES | — | 1991-01-30 | — | — | EP | disclosed |
| EP-0375726-A1 | MELATONIN ANALOGUES | Whitby Research Incorporated (US) | 1990-07-04 | — | — | EP | disclosed |
| WO-1989001472-A1 | MELATONIN ANALOGUES | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-02-23 | — | — | WO | disclosed |