Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL106428 | 0.92 | SPHK1 (0.50) | TSHRTP53EPHX1EPHX2CDK9 | |
| SCHEMBL19026945 | 0.91 | SPHK1 (0.50) | TSHRTP53EPHX1EPHX2CDK9 | |
| SCHEMBL17993520 | 0.91 | NAPRT (0.47) | TSHRTP53EPHX1EPHX2CDK9 | |
| SCHEMBL10202156 | 0.91 | TSHR (0.48) | TSHRTP53EPHX1EPHX2CDK9 | |
| SCHEMBL24444629 | 0.89 | LMNA (0.58) | TP53SMN1; SMN2MEN1KMT2ASPHK1 | |
| SCHEMBL558092 | 0.89 | POLB (0.55) | MEN1KMT2ASPHK1FAAH | |
| SCHEMBL14817483 | 0.88 | NAPRT (0.53) | TSHRTP53EPHX1EPHX2CDK9 | |
| SCHEMBL307975 | 0.88 | SPHK1 (0.55) | TSHRTP53EPHX1EPHX2CDK9 | |
| SCHEMBL138295 | 0.88 | MEN1 (0.51) | TSHRTP53EPHX1EPHX2CDK9 | |
| SCHEMBL25474863 | 0.88 | SPHK1 (0.58) | EPHX2MEN1KMT2ASPHK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024150252-A1 | PYRAZOLIDINE-3, 5-DIONE BASED COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2024-07-18 | — | — | WO | disclosed |
| EP-2768796-B1 | PROCESS FOR PREPARING QUINOLINE DERIVATIVES | EXELIXIS INC (US) | 2019-11-20 | — | — | EP | disclosed |
| US-9969692-B2 | Process for preparing quinoline derivatives | EXELIXIS, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969692-B2 | Process for preparing quinoline derivatives | EXELIXIS, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20160229805-A1 | Process for Preparing Quinoline Derivatives | EXELIXIS, INC. | 2016-08-11 | — | — | US | disclosed |
| US-9365516-B2 | Process for preparing quinoline derivatives | EXELIXIS, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20140256938-A1 | Process for Preparing Quinoline Derivatives | EXELIXIS, INC. | 2014-09-11 | — | — | US | disclosed |
| US-5334747-A | Reacting substituted malonic acid dialkyl ester with aniline in presence of stoichiometric amount of alkali alcoholate, neutralizing product with acid, saponifying with water | HULS AKTIENGESELLSCHAFT (DE) | 1994-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229805-A1 | Process for Preparing Quinoline Derivatives | C5, C1S, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | TSHR 1070/4885TP53 2433/4885EPHX1 1401/4885 |
| US-20140256938-A1 | Process for Preparing Quinoline Derivatives | C5, C1S, C1R | TSHR 1007/4885TP53 2328/4885EPHX1 1455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.