SCHEMBL9304566

SCHEMBL9304566

COc1ccc2[nH]c(I)nc2c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.48
KDM4E B2RXH2 6/20 0.48
MEN1 O00255 5/20 0.48
KMT2A Q03164 5/20 0.48
MAPT P10636 4/20 0.48
HSD17B10 Q99714 4/20 0.48
GFER P55789 2/20 0.48
TSHR P16473 2/20 0.48
CYP1A2 P05177 3/20 0.48
CYP2C19 P33261 3/20 0.48
AXL P30530 1/20 0.47
MMP12 P39900 1/20 0.46
NPC1 O15118 4/20 0.46
RAB9A P51151 4/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
LMNA P02545 1/20 0.46
POLB P06746 1/20 0.46
NQO2 P16083 1/20 0.46
HPGD P15428 3/20 0.44
TP53 P04637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9304583 0.86 NPC1 (0.58) ALDH1A1KDM4EMEN1KMT2AHSD17B10
SCHEMBL1170729 0.81 ALDH1A1 (0.57) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL1286065 0.80 KDM4E (0.57) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL31578181 0.80 ALDH1A1 (0.50) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL8895675 0.79 ALDH1A1 (0.55) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL1193199 0.79 ALDH1A1 (0.48) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL916531 0.79 ALDH1A1 (0.48) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL2163036 0.79 TYMS (0.52) ALDH1A1KDM4EMEN1KMT2AMAPT
Hydrochloric Acid SCHEMBL31587365 0.79 KDM4E (0.55) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL28264398 0.79 ALDH1A1 (0.48) ALDH1A1KDM4EMEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5347008-A Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents CIBA-GEIGY CORPORATION (US) 1994-09-13 US disclosed
US-5152929-A Corrosion inhibitors for water systems CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed
EP-0129506-A2 Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids CIBA-GEIGY AG (CH) 1984-12-27 EP disclosed