SCHEMBL9304576

SCHEMBL9304576

OC(=S)C(C(O)=S)c1nc2ccccc2[nH]1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.62
ALDH1A1 P00352 3/20 0.58
POLB P06746 1/20 0.58
GAA P10253 3/20 0.52
NPSR1 Q6W5P4 2/20 0.52
MAPT P10636 1/20 0.52
MLKL Q8NB16 3/20 0.50
KMT2A Q03164 3/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
ALOX12 P18054 1/20 0.49
TAAR1 Q96RJ0 1/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
KDM4E B2RXH2 1/20 0.47
ABCB11 O95342 1/20 0.47
TP53 P04637 1/20 0.47
PKM P14618 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HSD17B10 Q99714 1/20 0.47
CYP1A2 P05177 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9304581 0.90 IDO1 (0.56) IDO1ALDH1A1POLBGAANPSR1
SCHEMBL11019120 0.84 IDO1 (0.61) IDO1ALDH1A1POLBGAANPSR1
SCHEMBL11021656 0.83 IDO1 (0.59) IDO1ALDH1A1POLBGAANPSR1
SCHEMBL6063468 0.79 IDO1 (0.54) IDO1ALDH1A1POLBGAANPSR1
SCHEMBL12051733 0.79 IDO1 (0.62) IDO1ALDH1A1POLBGAAMAPT
Ammonia Solution, Strong SCHEMBL10866535 0.78 IDO1 (0.53) IDO1ALDH1A1POLBGAANPSR1
SCHEMBL4921708 0.77 IDO1 (1.00) IDO1ALDH1A1POLBGAANPSR1
SCHEMBL7946544 0.77 IDO1 (0.78) IDO1ALDH1A1POLBGAANPSR1
SCHEMBL9304570 0.77 IDO1 (0.56) IDO1ALDH1A1POLBGAAMLKL
SCHEMBL6063469 0.77 KMT2A (0.54) IDO1ALDH1A1POLBGAANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5347008-A Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents CIBA-GEIGY CORPORATION (US) 1994-09-13 US disclosed
US-5152929-A Corrosion inhibitors for water systems CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed
US-4612049-A BENZOTHI ZOLYL THIO-, BENZIMIDAZOLYLTHIO- OR BENZOXAZOLYLTHIO-SUBSTITUTED CARBOXY ACID CIBA-GEIGY CORPORATION (US) 1986-09-16 US disclosed
EP-0183647-A1 Anti-corrosive aqueous paints CIBA-GEIGY AG (CH) 1986-06-04 EP disclosed
EP-0129506-A2 Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids CIBA-GEIGY AG (CH) 1984-12-27 EP disclosed
EP-0128862-A2 Anti-corrosive coating composition CIBA-GEIGY AG (CH) 1984-12-19 EP disclosed