Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8134885 | 0.82 | PKM (0.61) | NPC1PKMRAB9AMAPTLMNA | |
| SCHEMBL9539135 | 0.77 | NPC1 (0.74) | NPC1PKMRAB9AMAPTLMNA | |
| SCHEMBL11554972 | 0.77 | GRM5 (0.58) | NPC1RAB9AMAPTSMN1; SMN2PDE10A | |
| SCHEMBL9634943 | 0.76 | PKM (0.57) | NPC1PKMRAB9AMAPTLMNA | |
| SCHEMBL4034758 | 0.76 | NPC1 (0.62) | NPC1PKMRAB9AMAPTLMNA | |
| SCHEMBL20797702 | 0.76 | NPC1 (0.55) | NPC1PKMRAB9AMAPTLMNA | |
| SCHEMBL4989679 | 0.76 | PKM (0.57) | NPC1PKMRAB9AMAPTLMNA | |
| SCHEMBL5119326 | 0.75 | PDE10A (0.60) | NPC1PKMRAB9AMAPTLMNA | |
| SCHEMBL31631301 | 0.75 | NPC1 (0.74) | NPC1PKMRAB9AMAPTLMNA | |
| SCHEMBL1738419 | 0.75 | NPC1 (0.74) | NPC1PKMRAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037770-C | Substituted thiazolyl and substituted pyridinyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1998-03-18 | — | — | CN | disclosed |
| US-5360807-A | Substituted thiazolyl and substituted pyridinyl derivatives | JANSSEN PHARMACEUTICA N.V. (BF) | 1994-11-01 | — | — | US | disclosed |
| EP-0539420-A1 | NOVEL SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001697-A1 | NOVEL SUBSTITUTED THIAZOLYL AND SUBSTITUTED PYRIDINYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-06 | — | — | WO | disclosed |