Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7774759 | 1.00 | HCAR2 (0.40) | HCAR2KEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL10430503 | 1.00 | HCAR2 (0.40) | HCAR2KEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL11146499 | 0.85 | NPSR1 (0.48) | HCAR2KEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL11146503 | 0.85 | NPSR1 (0.53) | HCAR2NPSR1ALDH1A1EGLN1 | |
| SCHEMBL11146493 | 0.85 | NPSR1 (0.53) | HCAR2NPSR1ALDH1A1EGLN1 | |
| SCHEMBL11148527 | 0.85 | NPSR1 (0.53) | HCAR2NPSR1ALDH1A1EGLN1 | |
| SCHEMBL11148529 | 0.85 | NPSR1 (0.48) | HCAR2KEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL7772525 | 0.83 | HCAR2 (0.37) | HCAR2KEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL6877098 | 0.83 | HCAR2 (0.37) | HCAR2KEAP1NFE2L2NPSR1ALDH1A1 | |
| SCHEMBL7767062 | 0.82 | KDM4E (0.43) | HCAR2NPSR1ALDH1A1TET2EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5275941-A | Chlorination or salt formation of aspartates in ethyl fumaric acid ester mixtures, separation and introducing a protective group to the nitrogen | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-01-04 | — | — | US | disclosed |
| US-4731467-A | Process for the preparation of a diester of a 2-butenedioic acid | SHELL OIL COMPANY (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0231044-A2 | Process for the preparation of a diester of a dicarboxylic acid | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1987-08-05 | — | — | EP | disclosed |
| US-4383053-A | Antifouling paints having fumaric acid ester polymer | NIPPON OIL AND FATS CO., LTD. (JP) | 1983-05-10 | — | — | US | disclosed |