Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9309095 | 1.00 | PTPN11 (0.40) | PTPN11THRATHRBCNR2CNR1 | |
| Iodide SCHEMBL9307741 | 0.94 | PTPN11 (0.41) | PTPN11THRATHRBCNR2CNR1 | |
| Iodide SCHEMBL9307202 | 0.94 | PTPN11 (0.41) | PTPN11THRATHRBCNR2CNR1 | |
| Iodide SCHEMBL9305966 | 0.88 | CNR1 (0.47) | THRATHRBCNR2CNR1NPSR1 | |
| Iodide SCHEMBL9305240 | 0.88 | CNR1 (0.47) | THRATHRBCNR2CNR1NPSR1 | |
| Iodide SCHEMBL9308082 | 0.86 | THRB (0.47) | PTPN11THRATHRB | |
| Iodide SCHEMBL9307338 | 0.86 | THRB (0.47) | PTPN11THRATHRB | |
| Iodide SCHEMBL9307343 | 0.83 | THRB (0.42) | THRATHRBCNR2CNR1 | |
| Iodide SCHEMBL9307084 | 0.83 | S1PR2 (0.45) | THRATHRBNPSR1 | |
| Iodide SCHEMBL9309198 | 0.83 | S1PR2 (0.45) | THRATHRBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |