Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenethylamine SCHEMBL9229966 | 0.94 | GAA (0.77) | GAAMAPTMEN1KMT2ATDP1 | |
| SCHEMBL8003698 | 0.92 | GAA (0.74) | GAAMAPTMEN1KMT2ATDP1 | |
| Putrescine SCHEMBL7991103 | 0.92 | GAA (0.74) | GAAMAPTMEN1KMT2ATDP1 | |
| SCHEMBL27228 | 0.91 | GAA (0.95) | GAAMAPTMEN1KMT2ATDP1 | |
| Ammonia Solution, Strong SCHEMBL23581968 | 0.89 | GAA (0.91) | GAAMAPTMEN1KMT2ATDP1 | |
| Ethylenediamine SCHEMBL8711121 | 0.89 | MEN1 (0.81) | GAAMAPTMEN1KMT2ATDP1 | |
| SCHEMBL11881258 | 0.89 | GAA (0.91) | GAAMAPTMEN1KMT2ATDP1 | |
| SCHEMBL25432637 | 0.89 | GAA (0.91) | GAAMAPTMEN1KMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL1983401 | 0.89 | GAA (1.00) | GAAMAPTMEN1KMT2ATDP1 | |
| SCHEMBL3272134 | 0.89 | GAA (0.91) | GAAMAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5312821-A | Antiulcer agents | WARNER-LAMBERT COMPANY (US) | 1994-05-17 | — | — | US | disclosed |
| EP-0249236-A1 | N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof | WARNER-LAMBERT COMPANY (US) | 1987-12-16 | — | — | EP | disclosed |