Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307274 | 0.92 | THRA (0.53) | THRATHRBSMPD1CNR2EPHX2 | |
| Iodide SCHEMBL9307265 | 0.92 | THRA (0.53) | THRATHRBSMPD1CNR2EPHX2 | |
| Iodide SCHEMBL9307387 | 0.92 | THRA (0.53) | THRATHRBSMPD1CNR2EPHX2 | |
| Iodide SCHEMBL9306202 | 0.90 | THRA (0.48) | THRATHRB | |
| Iodide SCHEMBL9306329 | 0.90 | THRA (0.48) | THRATHRB | |
| Iodide SCHEMBL9306964 | 0.89 | THRA (0.50) | THRATHRBSMPD1CNR2 | |
| Iodide SCHEMBL9307333 | 0.86 | POLB (0.52) | THRATHRBSMPD1CNR2 | |
| Iodide SCHEMBL9306636 | 0.86 | POLB (0.52) | THRATHRBSMPD1CNR2 | |
| Iodide SCHEMBL9307915 | 0.86 | SMPD1 (0.59) | SMPD1CNR2NR1H4 | |
| Iodide SCHEMBL9309300 | 0.85 | THRA (0.45) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |