Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303549 | 0.93 | KDM4E (0.39) | HRH1HRH4KDM4EHSD17B10TSHR | |
| SCHEMBL8137072 | 0.86 | ALDH1A1 (0.39) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL9306122 | 0.86 | HSD17B10 (0.47) | KDM4EHSD17B10TSHRKMT2ALMNA | |
| SCHEMBL9304627 | 0.85 | CYP2D6 (0.41) | KDM4EHSD17B10TSHRMEN1KMT2A | |
| SCHEMBL5359047 | 0.85 | KDM4E (0.38) | KDM4EHSD17B10TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8134231 | 0.84 | HSD17B10 (0.46) | KDM4EHSD17B10TSHRKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL8142868 | 0.84 | CYP2D6 (0.40) | KDM4EMEN1KMT2ALMNAMAPT | |
| SCHEMBL9303541 | 0.83 | CYP2D6 (0.47) | KDM4EHSD17B10TSHRKCNH2ALDH1A1 | |
| SCHEMBL9258008 | 0.83 | NAMPT (0.39) | KDM4EHSD17B10TSHRMAPTMERTK | |
| Hydrochloric Acid SCHEMBL8127101 | 0.81 | CYP2D6 (0.46) | KDM4EHSD17B10TSHRKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296491-A | Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | claimed |