Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242716 | 0.92 | LMNA (0.57) | ELANELMNATSHRF2CES2 | |
| SCHEMBL28868136 | 0.90 | LMNA (0.55) | ELANELMNATSHRF2CES2 | |
| SCHEMBL20531234 | 0.90 | LMNA (0.55) | ELANELMNATSHRF2CES2 | |
| SCHEMBL8853090 | 0.90 | LMNA (0.55) | ELANELMNATSHRF2CES2 | |
| SCHEMBL25220849 | 0.89 | LMNA (0.53) | ELANELMNATSHRF2CES2 | |
| SCHEMBL28160533 | 0.89 | LMNA (0.53) | ELANELMNATSHRF2CES2 | |
| SCHEMBL9858271 | 0.86 | LMNA (0.55) | ELANELMNATSHRF2CES2 | |
| SCHEMBL9494449 | 0.86 | LMNA (0.55) | ELANELMNATSHRF2CES2 | |
| SCHEMBL8309453 | 0.85 | SMN1; SMN2 (0.61) | ELANESMN1; SMN2KMT2AMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL25258598 | 0.84 | SMN1; SMN2 (0.59) | ELANESMN1; SMN2KMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5336686-A | Glucocorticoid, progesterone and androgen antagonists; hormone inhibitors; antiproliferative activity; antitumor and carcinogenic agents | ROUSSEL-UCLAF (FR) | 1994-08-09 | — | — | US | disclosed |