Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306330 | 1.00 | THRB (0.42) | THRBTHRACNR2MEN1ALDH1A1 | |
| Iodide SCHEMBL9307343 | 0.94 | THRB (0.42) | THRBTHRACNR2MEN1ALDH1A1 | |
| Iodide SCHEMBL9307388 | 0.91 | THRB (0.43) | THRBTHRACNR2MEN1ALDH1A1 | |
| Iodide SCHEMBL9307810 | 0.91 | THRB (0.43) | THRBTHRACNR2MEN1ALDH1A1 | |
| Iodide SCHEMBL9309460 | 0.89 | CNR2 (0.42) | THRBTHRACNR2LMNA | |
| Iodide SCHEMBL9307581 | 0.89 | CNR2 (0.42) | THRBTHRACNR2LMNA | |
| Iodide SCHEMBL9305722 | 0.87 | CNR1 (0.50) | THRBTHRACNR2CNR1 | |
| Iodide SCHEMBL9305950 | 0.87 | CNR1 (0.50) | THRBTHRACNR2CNR1 | |
| Iodide SCHEMBL9305547 | 0.86 | THRB (0.51) | THRBTHRAALDH1A1FAAHLMNA | |
| Iodide SCHEMBL9306867 | 0.86 | THRB (0.51) | THRBTHRAALDH1A1FAAHLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |