SCHEMBL9306401

SCHEMBL9306401

Nc1cc2nc(C(CC(=O)O)C(O)=S)[nH]c2cc1C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CACNA1H O95180 3/20 0.38
PRKCZ Q05513 1/20 0.36
SCN10A Q9Y5Y9 2/20 0.35
EGLN1 Q9GZT9 6/20 0.35
S1PR4 O95977 3/20 0.32
S1PR1 P21453 3/20 0.32
S1PR5 Q9H228 2/20 0.32
CACNA1G O43497 1/20 0.32
CACNA1C Q13936 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9306398 0.86 CACNA1H (0.39) CACNA1HSCN10AEGLN1CACNA1GCACNA1C
SCHEMBL9306392 0.78 CACNA1H (0.39) CACNA1HPRKCZSCN10AEGLN1S1PR4
SCHEMBL9307003 0.77 HSD17B10 (0.45) EGLN1
SCHEMBL6063469 0.71 KMT2A (0.54)
Methylamine SCHEMBL10866959 0.71 KMT2A (0.54)
Ammonia Solution, Strong SCHEMBL10866540 0.70 KMT2A (0.53)
SCHEMBL6602090 0.69 GRIA1 (0.56) EGLN1
Dimethylamine SCHEMBL10893464 0.68 KMT2A (0.53)
SCHEMBL9306997 0.66 MEN1 (0.42) EGLN1
Diethylamine SCHEMBL10868574 0.65 KMT2A (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5347008-A Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents CIBA-GEIGY CORPORATION (US) 1994-09-13 US disclosed
US-5152929-A Corrosion inhibitors for water systems CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed