Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9308353 | 1.00 | THRA (0.48) | THRATHRBSMPD1MEN1MAPT | |
| Iodide SCHEMBL9306964 | 0.91 | THRA (0.50) | THRATHRBSMPD1CNR2 | |
| Iodide SCHEMBL9307274 | 0.90 | THRA (0.53) | THRATHRBSMPD1CNR2 | |
| Iodide SCHEMBL9306246 | 0.88 | NPSR1 (0.41) | THRATHRBMEN1MAPTMAPK1 | |
| Iodide SCHEMBL9307697 | 0.88 | NPSR1 (0.41) | THRATHRBMEN1MAPTMAPK1 | |
| Iodide SCHEMBL9307008 | 0.87 | SMPD1 (0.54) | SMPD1NPSR1CNR2 | |
| Iodide SCHEMBL9305581 | 0.87 | POLB (0.50) | THRATHRBSMPD1CNR2 | |
| Iodide SCHEMBL9306985 | 0.87 | SMPD1 (0.54) | SMPD1NPSR1CNR2 | |
| Iodide SCHEMBL9307637 | 0.87 | POLB (0.50) | THRATHRBSMPD1CNR2 | |
| Iodide SCHEMBL9307265 | 0.84 | THRA (0.53) | THRATHRBSMPD1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |