Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306561 | 0.94 | CNR2 (0.43) | CNR2CNR1POLB | |
| Iodide SCHEMBL9307289 | 0.91 | CNR2 (0.45) | CNR2 | |
| Iodide SCHEMBL9306770 | 0.89 | CNR2 (0.45) | CNR2CNR1POLBTSHRHTT | |
| Iodide SCHEMBL9308634 | 0.89 | ALDH1A1 (0.45) | CNR2CNR1TSHRHTT | |
| Iodide SCHEMBL9306019 | 0.86 | CNR2 (0.45) | CNR2CNR1HTT | |
| Iodide SCHEMBL9305691 | 0.86 | CNR2 (0.45) | CNR2CNR1POLBTSHRHTT | |
| Iodide SCHEMBL9307152 | 0.86 | CNR2 (0.46) | CNR2CNR1POLBTSHRHTT | |
| Iodide SCHEMBL9307061 | 0.85 | CNR2 (0.45) | CNR2CNR1TSHRHTT | |
| Iodide SCHEMBL9306653 | 0.84 | CNR2 (0.45) | CNR2CNR1POLBTSHRHTT | |
| Iodide SCHEMBL9306086 | 0.84 | ALDH1A1 (0.45) | CNR2TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |