Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 20/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306791 | 1.00 | SIGMAR1 (0.97) | SIGMAR1 | |
| SCHEMBL9306789 | 1.00 | SIGMAR1 (0.97) | SIGMAR1 | |
| SCHEMBL7381707 | 0.93 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9306849 | 0.78 | SIGMAR1 (0.97) | SIGMAR1 | |
| SCHEMBL9308016 | 0.78 | SIGMAR1 (0.97) | SIGMAR1 | |
| SCHEMBL29016989 | 0.76 | SIGMAR1 (0.68) | SIGMAR1 | |
| SCHEMBL9307181 | 0.76 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9307177 | 0.76 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9307179 | 0.76 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL11460515 | 0.74 | SIGMAR1 (0.56) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410535-A2 | Octahydrobenzisoquinoline derivatives as antipsychotic agents | MERCK SHARP & DOHME LTD. (GB) | 1991-01-30 | — | — | EP | claimed |
| US-5294618-A | Psychological disorders | MERCK SHARP & DOHME LIMITED (GB) | 1994-03-15 | — | — | US | disclosed |
| EP-0410535-A2 | Octahydrobenzisoquinoline derivatives as antipsychotic agents | MERCK SHARP & DOHME LTD. (GB) | 1991-01-30 | — | — | EP | disclosed |