Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9305282 | 1.00 | S1PR2 (0.45) | S1PR2S1PR1S1PR3LPAR2NPSR1 | |
| Iodide SCHEMBL9307883 | 0.94 | S1PR2 (0.46) | S1PR2S1PR1S1PR3LPAR2NPSR1 | |
| Iodide SCHEMBL9307184 | 0.94 | S1PR2 (0.46) | S1PR2S1PR1S1PR3LPAR2NPSR1 | |
| Iodide SCHEMBL9305749 | 0.90 | S1PR2 (0.48) | S1PR2S1PR1S1PR3LPAR2NPSR1 | |
| Iodide SCHEMBL9307396 | 0.90 | S1PR2 (0.48) | S1PR2S1PR1S1PR3LPAR2NPSR1 | |
| Iodide SCHEMBL9309311 | 0.89 | HSD17B10 (0.55) | NPSR1HSD17B10MEN1KMT2AEPHX2 | |
| Iodide SCHEMBL9307697 | 0.88 | NPSR1 (0.41) | NPSR1HSD17B10MEN1KMT2AMAPT | |
| Iodide SCHEMBL9306246 | 0.88 | NPSR1 (0.41) | NPSR1HSD17B10MEN1KMT2AMAPT | |
| Iodide SCHEMBL9305581 | 0.87 | POLB (0.50) | S1PR2S1PR1S1PR3LPAR2LMNA | |
| Iodide SCHEMBL9307637 | 0.87 | POLB (0.50) | S1PR2S1PR1S1PR3LPAR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |