Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307156 | 0.94 | HSD17B10 (0.57) | HSD17B10EPHX2NPSR1POLBMEN1 | |
| Iodide SCHEMBL9309538 | 0.94 | HSD17B10 (0.57) | HSD17B10EPHX2NPSR1POLBMEN1 | |
| Iodide SCHEMBL9308081 | 0.90 | HSD17B10 (0.57) | HSD17B10EPHX2NPSR1 | |
| Iodide SCHEMBL9307295 | 0.90 | HSD17B10 (0.57) | HSD17B10EPHX2NPSR1 | |
| Iodide SCHEMBL9305282 | 0.89 | S1PR2 (0.45) | HSD17B10EPHX2NPSR1POLBMEN1 | |
| Iodide SCHEMBL9306863 | 0.89 | S1PR2 (0.45) | HSD17B10EPHX2NPSR1POLBMEN1 | |
| Iodide SCHEMBL9307697 | 0.88 | NPSR1 (0.41) | HSD17B10NPSR1POLBMEN1KMT2A | |
| Iodide SCHEMBL9306246 | 0.88 | NPSR1 (0.41) | HSD17B10NPSR1POLBMEN1KMT2A | |
| Iodide SCHEMBL9306985 | 0.87 | SMPD1 (0.54) | NPSR1CNR2 | |
| Iodide SCHEMBL9307008 | 0.87 | SMPD1 (0.54) | NPSR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |