Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9308674 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2MTNR1AMAPTALDH1A1PLA2G4B | |
| Iodide SCHEMBL9307316 | 0.97 | SMN1; SMN2 (0.47) | SMN1; SMN2MTNR1AMAPTALDH1A1PLA2G4B | |
| Iodide SCHEMBL9306741 | 0.97 | SMN1; SMN2 (0.47) | SMN1; SMN2MTNR1AMAPTALDH1A1PLA2G4B | |
| Iodide SCHEMBL9306469 | 0.95 | SMN1; SMN2 (0.46) | SMN1; SMN2MTNR1AMAPTALDH1A1PLA2G4B | |
| Iodide SCHEMBL9306540 | 0.95 | SMN1; SMN2 (0.46) | SMN1; SMN2MTNR1AMAPTALDH1A1PLA2G4B | |
| Iodide SCHEMBL9307744 | 0.91 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTALDH1A1PLA2G4BLMNA | |
| Iodide SCHEMBL9308554 | 0.91 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTALDH1A1PLA2G4BLMNA | |
| Iodide SCHEMBL9307937 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2MTNR1AMAPTALDH1A1PLA2G4B | |
| Iodide SCHEMBL9307735 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2MTNR1AMAPTALDH1A1PLA2G4B | |
| Iodide SCHEMBL9308398 | 0.90 | ALDH1A1 (0.48) | SMN1; SMN2MAPTALDH1A1PLA2G4BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |