Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 5/20 | 0.60 |
| ▸ | CNR2 | P34972 | 3/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307245 | 1.00 | SMPD1 (0.60) | SMPD1CNR2NR1H4L3MBTL1THRA | |
| Iodide SCHEMBL9306394 | 0.95 | SMPD1 (0.59) | SMPD1CNR2NR1H4L3MBTL1THRA | |
| Iodide SCHEMBL9307915 | 0.93 | SMPD1 (0.59) | SMPD1CNR2NR1H4 | |
| Iodide SCHEMBL9308584 | 0.89 | S1PR2 (0.56) | SMPD1 | |
| Iodide SCHEMBL9308248 | 0.89 | S1PR2 (0.56) | SMPD1 | |
| Iodide SCHEMBL9307700 | 0.88 | POLB (0.52) | SMPD1CNR2THRATHRB | |
| Iodide SCHEMBL9307073 | 0.88 | POLB (0.52) | SMPD1CNR2THRATHRB | |
| Iodide SCHEMBL9306480 | 0.88 | SMPD1 (0.56) | SMPD1CNR2L3MBTL1ROCK2 | |
| Iodide SCHEMBL9307357 | 0.88 | SMPD1 (0.56) | SMPD1CNR2L3MBTL1ROCK2 | |
| Iodide SCHEMBL9307265 | 0.87 | THRA (0.53) | SMPD1CNR2NR1H4THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |