Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 5/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307547 | 1.00 | SMPD1 (0.47) | SMPD1TAS1R3TAS1R1NPSR1LMNA | |
| Iodide SCHEMBL9306238 | 0.95 | SMPD1 (0.47) | SMPD1TAS1R3TAS1R1NPSR1LMNA | |
| Iodide SCHEMBL9307894 | 0.91 | SMPD1 (0.47) | SMPD1TAS1R3TAS1R1NPSR1LMNA | |
| Iodide SCHEMBL9307588 | 0.89 | THRA (0.43) | SMPD1TAS1R3TAS1R1NPSR1THRA | |
| Iodide SCHEMBL9307774 | 0.89 | THRA (0.43) | SMPD1TAS1R3TAS1R1NPSR1THRA | |
| Iodide SCHEMBL9307918 | 0.88 | THRA (0.45) | SMPD1TAS1R3TAS1R1NPSR1MAPT | |
| Iodide SCHEMBL9309375 | 0.88 | THRA (0.45) | SMPD1TAS1R3TAS1R1NPSR1MAPT | |
| Iodide SCHEMBL9307639 | 0.88 | THRA (0.45) | SMPD1TAS1R3TAS1R1NPSR1MAPT | |
| Iodide SCHEMBL9306302 | 0.85 | THRA (0.43) | SMPD1TAS1R3TAS1R1NPSR1THRA | |
| Iodide SCHEMBL9306499 | 0.85 | THRA (0.43) | SMPD1TAS1R3TAS1R1NPSR1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |