Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9306280 | 0.92 | TP53 (0.42) | TP53MAPTTHRATHRBRAF1 | |
| Iodide SCHEMBL9309193 | 0.92 | TP53 (0.46) | TP53MAPTTHRATHRB | |
| Iodide SCHEMBL9306993 | 0.91 | TP53 (0.46) | TP53MAPTTHRATHRBRAF1 | |
| Iodide SCHEMBL9307752 | 0.89 | THRA (0.46) | THRATHRB | |
| Iodide SCHEMBL9306538 | 0.88 | TP53 (0.46) | TP53MAPTTHRATHRBRAF1 | |
| Iodide SCHEMBL9308303 | 0.83 | ATM (0.40) | RAF1MAP2K1 | |
| Iodide SCHEMBL9308462 | 0.83 | THRA (0.40) | THRATHRB | |
| Iodide SCHEMBL9307400 | 0.82 | MAPT (0.45) | TP53MAPTTHRATHRBRAF1 | |
| Iodide SCHEMBL9307898 | 0.82 | THRA (0.40) | MAPTTHRATHRB | |
| Iodide SCHEMBL9306025 | 0.82 | THRA (0.42) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |