Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.57 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.57 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.57 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5090844 | 0.88 | SMPD1 (0.53) | S1PR1S1PR3S1PR2LPAR2PTPN11 | |
| SCHEMBL6561819 | 0.87 | S1PR2 (0.43) | S1PR1S1PR3S1PR2LPAR2THRA | |
| SCHEMBL7039087 | 0.85 | ALDH1A1 (0.43) | S1PR1S1PR3S1PR2LPAR2TLR7 | |
| SCHEMBL4843750 | 0.85 | ALDH1A1 (0.49) | — | |
| SCHEMBL9307491 | 0.84 | S1PR2 (0.57) | S1PR1S1PR3S1PR2LPAR2THRA | |
| SCHEMBL28538792 | 0.80 | MAPT (0.58) | THRATHRB | |
| SCHEMBL28538873 | 0.80 | MAPT (0.58) | THRATHRB | |
| SCHEMBL28534185 | 0.80 | MAPT (0.58) | THRATHRB | |
| SCHEMBL1039522 | 0.80 | HTT (0.51) | — | |
| SCHEMBL21467393 | 0.80 | S1PR1 (0.56) | S1PR1S1PR3S1PR2LPAR2THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |