Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 11/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9307365 | 0.94 | CNR2 (0.49) | CNR2MAPTHTTRAD52MEN1 | |
| Iodide SCHEMBL9307893 | 0.92 | CNR2 (0.46) | CNR2MAPTHTTRAD52MEN1 | |
| Iodide SCHEMBL9305875 | 0.92 | CNR2 (0.50) | CNR2MAPTHTTTHRBCNR1 | |
| Iodide SCHEMBL9306247 | 0.87 | S1PR2 (0.42) | MAPTHTTRAD52MEN1MAPK1 | |
| Iodide SCHEMBL9306470 | 0.87 | S1PR2 (0.42) | MAPTHTTRAD52MEN1MAPK1 | |
| Iodide SCHEMBL9305091 | 0.86 | CNR2 (0.48) | CNR2MAPTHTTTHRBCNR1 | |
| Iodide SCHEMBL9307171 | 0.84 | ALDH1A1 (0.47) | CNR2MAPTHTTLMNATSHR | |
| Iodide SCHEMBL9306786 | 0.84 | CNR2 (0.46) | CNR2MAPTTHRB | |
| Iodide SCHEMBL9306770 | 0.84 | CNR2 (0.45) | CNR2MAPTHTTTHRBCNR1 | |
| Iodide SCHEMBL9306019 | 0.82 | CNR2 (0.45) | CNR2MAPTHTTRAD52MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |